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Dissect the DNMT3A- and DNMT3B-mediated DNA co-methylation through a covalent complex approach
DNA methylation plays a critical role in regulating gene expression, genomic stability and cell fate commitment. Mammalian DNA methylation, which mostly occurs in the context of CpG dinucleotide, is installed by two do novo DNA methyltransferases, DNMT3A and DNMT3B. Oligomerization of DNMT3A and DNM...
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| Veröffentlicht in: | J Mol Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6995754/ https://ncbi.nlm.nih.gov/pubmed/31726062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.11.004 |
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