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DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the targe...
Kaydedildi:
| Yayımlandı: | Nat Commun |
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| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7381644/ https://ncbi.nlm.nih.gov/pubmed/32709850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17531-8 |
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