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Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular basis remains undetermined. Through comprehensive structural, enzymology and cellular chara...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gao, Linfeng, Emperle, Max, Guo, Yiran, Grimm, Sara A., Ren, Wendan, Adam, Sabrina, Uryu, Hidetaka, Zhang, Zhi-Min, Chen, Dongliang, Yin, Jiekai, Dukatz, Michael, Anteneh, Hiwot, Jurkowska, Renata Z., Lu, Jiuwei, Wang, Yinsheng, Bashtrykov, Pavel, Wade, Paul A., Wang, Gang Greg, Jeltsch, Albert, Song, Jikui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335073/
https://ncbi.nlm.nih.gov/pubmed/32620778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17109-4
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