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Structural basis for DNMT3A-mediated de novo DNA methylation
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) is essential for genome regulation and development(1, 2). Dysregulation of this process is implicated in various diseases, notably cancer. However, the mechanisms underlying DNMT3 substrate recognition and enzymatic specif...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5814352/ https://ncbi.nlm.nih.gov/pubmed/29414941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25477 |
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