Structural basis for DNMT3A-mediated de novo DNA methylation

DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) is essential for genome regulation and development(1, 2). Dysregulation of this process is implicated in various diseases, notably cancer. However, the mechanisms underlying DNMT3 substrate recognition and enzymatic specif...

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Udgivet i:Nature
Main Authors: Zhang, Zhi-Min, Lu, Rui, Wang, Pengcheng, Yu, Yang, Chen, Dong-Liang, Gao, Linfeng, Liu, Shuo, Ji, Debin, Rothbart, Scott B, Wang, Yinsheng, Wang, Gang Greg, Song, Jikui
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814352/
https://ncbi.nlm.nih.gov/pubmed/29414941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25477
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