The Role of IFNγ-Producing Th1 Cells in a Type I IFN-Independent Murine Model of Autoinflammation Resulting from DNase II-Deficiency

OBJECTIVE: Patients with hypomorphic mutations in DNase II develop a severe and debilitating autoinflammatory disease. The objectives of this study were to compare disease parameters of these patients to a murine model of DNase II deficiency, evaluate the role of specific nucleic acid sensors and id...

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Pubblicato in:Arthritis Rheumatol
Autori principali: Pawaria, Sudesh, Nündel, Kerstin, Gao, Kevin M., Moses, Stephanie, Busto, Patricia, Holt, Kevin, Sharma, Rohit B., Brehm, Michael A., Gravallese, Ellen M., Socolovsky, Merav, Christ, Anette, Marshak-Rothstein, Ann
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994331/
https://ncbi.nlm.nih.gov/pubmed/31464028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41090
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