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DNase II-deficiency Prevents Activation of Autoreactive B cells by dsDNA Endogenous Ligands
In mice that fail to express the phagolysosomal endonuclease, DNase II, and the type I IFN receptor, excessive accrual of undegraded DNA results in a STING-dependent, TLR-independent inflammatory arthritis. These double knockout (DKO) mice develop additional indications of systemic autoimmunity, inc...
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| Udgivet i: | J Immunol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4323726/ https://ncbi.nlm.nih.gov/pubmed/25601924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402893 |
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