DNase II-deficiency Prevents Activation of Autoreactive B cells by dsDNA Endogenous Ligands

In mice that fail to express the phagolysosomal endonuclease, DNase II, and the type I IFN receptor, excessive accrual of undegraded DNA results in a STING-dependent, TLR-independent inflammatory arthritis. These double knockout (DKO) mice develop additional indications of systemic autoimmunity, inc...

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Gepubliceerd in:J Immunol
Hoofdauteurs: Pawaria, Sudesh, Moody, Krishna, Busto, Patricia, Nündel, Kerstin, Choi, Chee-Ho, Ghayur, Tariq, Marshak-Rothstein, Ann
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323726/
https://ncbi.nlm.nih.gov/pubmed/25601924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402893
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