DNase II-deficiency Prevents Activation of Autoreactive B cells by dsDNA Endogenous Ligands

In mice that fail to express the phagolysosomal endonuclease, DNase II, and the type I IFN receptor, excessive accrual of undegraded DNA results in a STING-dependent, TLR-independent inflammatory arthritis. These double knockout (DKO) mice develop additional indications of systemic autoimmunity, inc...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Immunol
Huvudupphovsmän: Pawaria, Sudesh, Moody, Krishna, Busto, Patricia, Nündel, Kerstin, Choi, Chee-Ho, Ghayur, Tariq, Marshak-Rothstein, Ann
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323726/
https://ncbi.nlm.nih.gov/pubmed/25601924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402893
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk