An Unexpected Role for RNA-sensing Toll-like Receptors in a Murine Model of DNA Accrual

OBJECTIVE: The goal of this study was to determine whether endosomal Toll-like receptors (TLRs) contribute to the clinical manifestation of systemic autoimmunity exhibited by mice that lack the lysosomal nuclease DNaseII. METHODS: DNaseII/IFNaR double deficient mice were intercrossed with Unc93b1(3d...

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Detalhes bibliográficos
Publicado no:Clin Exp Rheumatol
Main Authors: Pawaria, Sudesh, Moody, Krishna L., Busto, Patricia, Nündel, Kerstin, Baum, Rebecca, Sharma, Shruti, Gravallese, Ellen M., Fitzgerald, Katherine A., Marshak-Rothstein, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731237/
https://ncbi.nlm.nih.gov/pubmed/26457825
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