Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax

Inhalation of Bacillus anthracis spores can cause a rapidly progressing fatal infection. B. anthracis secretes three protein toxins: lethal factor (LF), edema factor (EF), and protective antigen (PA). EF and LF may circulate as free or PA-bound forms. Both free EF (EF) and PA-bound-EF (ETx) have ade...

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Detalhes bibliográficos
Publicado no:Anal Bioanal Chem
Main Authors: Lins, Renato C., Boyer, Anne E., Kuklenyik, Zsuzsanna, Woolfitt, Adrian R., Goldstein, Jason, Hoffmaster, Alex R., Gallegos-Candela, Maribel, Leysath, Clinton E., Chen, Zhaochun, Brumlow, Judith O., Quinn, Conrad P., Bagarozzi, Dennis A., Leppla, Stephen H., Barr, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988385/
https://ncbi.nlm.nih.gov/pubmed/30911800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-019-01730-4
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