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Nuclear and Cytoplasmatic Quantification of Unconjugated, Label-Free Locked Nucleic Acid Oligonucleotides

Methods for the quantification of antisense oligonucleotides (AONs) provide insightful information on biodistribution and intracellular trafficking. However, the established methods have not provided information on the absolute number of molecules in subcellular compartments or about how many AONs a...

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Bibliografiske detaljer
Udgivet i:Nucleic Acid Ther
Main Authors: Pendergraff, Hannah, Schmidt, Steffen, Vikeså, Jonas, Weile, Christian, Øverup, Charlotte, W. Lindholm, Marie, Koch, Troels
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987631/
https://ncbi.nlm.nih.gov/pubmed/31618108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0810
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