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Nuclear and Cytoplasmatic Quantification of Unconjugated, Label-Free Locked Nucleic Acid Oligonucleotides

Methods for the quantification of antisense oligonucleotides (AONs) provide insightful information on biodistribution and intracellular trafficking. However, the established methods have not provided information on the absolute number of molecules in subcellular compartments or about how many AONs a...

Полное описание

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Библиографические подробности
Опубликовано в: :Nucleic Acid Ther
Главные авторы: Pendergraff, Hannah, Schmidt, Steffen, Vikeså, Jonas, Weile, Christian, Øverup, Charlotte, W. Lindholm, Marie, Koch, Troels
Формат: Artigo
Язык:Inglês
Опубликовано: Mary Ann Liebert, Inc., publishers 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987631/
https://ncbi.nlm.nih.gov/pubmed/31618108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0810
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