Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells

Many cellular models aimed at elucidating cancer biology do not recapitulate pathobiology including tumor heterogeneity, an inherent feature of cancer that underlies treatment resistance. Here we introduce a cancer modeling paradigm using genetically engineered human pluripotent stem cells (hiPSCs)...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Koga, Tomoyuki, Chaim, Isaac A., Benitez, Jorge A., Markmiller, Sebastian, Parisian, Alison D., Hevner, Robert F., Turner, Kristen M., Hessenauer, Florian M., D’Antonio, Matteo, Nguyen, Nam-phuong D., Saberi, Shahram, Ma, Jianhui, Miki, Shunichiro, Boyer, Antonia D., Ravits, John, Frazer, Kelly A., Bafna, Vineet, Chen, Clark C., Mischel, Paul S., Yeo, Gene W., Furnari, Frank B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987220/
https://ncbi.nlm.nih.gov/pubmed/31992716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14312-1
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