mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

Central to cellular metabolism and cell proliferation are highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK)(1,2), dysregulation of which are implicated in pathogenesis of major human diseases such as cancer and type 2 diab...

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Détails bibliographiques
Publié dans:Nat Metab
Auteurs principaux: Ling, Naomi X.Y., Kaczmarek, Adrian, Hoque, Ashfaqul, Davie, Elizabeth, Ngoei, Kevin R.W., Morrison, Kaitlin R., Smiles, William J., Forte, Gabriella M., Wang, Tingting, Lie, Shervi, Dite, Toby A., Langendorf, Christopher G., Scott, John W., Oakhill, Jonathan S., Petersen, Janni
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986917/
https://ncbi.nlm.nih.gov/pubmed/31993556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0157-1
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