mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

Central to cellular metabolism and cell proliferation are highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK)(1,2), dysregulation of which are implicated in pathogenesis of major human diseases such as cancer and type 2 diab...

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Bibliografiske detaljer
Udgivet i:Nat Metab
Main Authors: Ling, Naomi X.Y., Kaczmarek, Adrian, Hoque, Ashfaqul, Davie, Elizabeth, Ngoei, Kevin R.W., Morrison, Kaitlin R., Smiles, William J., Forte, Gabriella M., Wang, Tingting, Lie, Shervi, Dite, Toby A., Langendorf, Christopher G., Scott, John W., Oakhill, Jonathan S., Petersen, Janni
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986917/
https://ncbi.nlm.nih.gov/pubmed/31993556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0157-1
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