mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

Central to cellular metabolism and cell proliferation are highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK)(1,2), dysregulation of which are implicated in pathogenesis of major human diseases such as cancer and type 2 diab...

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Detaylı Bibliyografya
Yayımlandı:Nat Metab
Asıl Yazarlar: Ling, Naomi X.Y., Kaczmarek, Adrian, Hoque, Ashfaqul, Davie, Elizabeth, Ngoei, Kevin R.W., Morrison, Kaitlin R., Smiles, William J., Forte, Gabriella M., Wang, Tingting, Lie, Shervi, Dite, Toby A., Langendorf, Christopher G., Scott, John W., Oakhill, Jonathan S., Petersen, Janni
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986917/
https://ncbi.nlm.nih.gov/pubmed/31993556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0157-1
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