Adenine base editing in an adult mouse model of tyrosinemia

Unlike traditional CRISPR-Cas9 homology-directed repair, base editing can correct point mutations without supplying a DNA-repair template. Here, we show in a mouse model of tyrosinemia that hydrodynamic tail-vein injection of plasmid DNA encoding the adenine base editor (ABE) and a single guide RNA...

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Detalhes bibliográficos
Publicado no:Nat Biomed Eng
Main Authors: Song, Chun-Qing, Jiang, Tingting, Richter, Michelle, Rhym, Luke H., Koblan, Luke W., Zafra, Maria Paz, Schatoff, Emma M, Doman, Jordan L., Cao, Yueying, Dow, Lukas E., Zhu, Lihua Julie, Anderson, Daniel G, Liu, David R., Yin, Hao, Xue, Wen
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986236/
https://ncbi.nlm.nih.gov/pubmed/31740768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-019-0357-8
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