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Adenine base editing in an adult mouse model of tyrosinemia
Unlike traditional CRISPR-Cas9 homology-directed repair, base editing can correct point mutations without supplying a DNA-repair template. Here, we show in a mouse model of tyrosinemia that hydrodynamic tail-vein injection of plasmid DNA encoding the adenine base editor (ABE) and a single guide RNA...
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| Pubblicato in: | Nat Biomed Eng |
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| Autori principali: | , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6986236/ https://ncbi.nlm.nih.gov/pubmed/31740768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-019-0357-8 |
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