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Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
Base editors enable targeted single-nucleotide conversion in genomic DNA. Here we show that expression levels are a bottleneck in base editing efficiency. We optimize cytidine (BE4) and adenine (ABE7.10) base editors by modification of nuclear localization signals and codon usage, and ancestral reco...
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| Publicat a: | Nat Biotechnol |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6126947/ https://ncbi.nlm.nih.gov/pubmed/29813047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4172 |
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