Carregant...

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

Base editors enable targeted single-nucleotide conversion in genomic DNA. Here we show that expression levels are a bottleneck in base editing efficiency. We optimize cytidine (BE4) and adenine (ABE7.10) base editors by modification of nuclear localization signals and codon usage, and ancestral reco...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Biotechnol
Autors principals: Koblan, Luke W., Doman, Jordan L., Wilson, Christopher, Levy, Jonathan M., Tay, Tristan, Newby, Greg A., Maianti, Juan Pablo, Raguram, Aditya, Liu, David R.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126947/
https://ncbi.nlm.nih.gov/pubmed/29813047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4172
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!