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Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
Base editors enable targeted single-nucleotide conversion in genomic DNA. Here we show that expression levels are a bottleneck in base editing efficiency. We optimize cytidine (BE4) and adenine (ABE7.10) base editors by modification of nuclear localization signals and codon usage, and ancestral reco...
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| Veröffentlicht in: | Nat Biotechnol |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6126947/ https://ncbi.nlm.nih.gov/pubmed/29813047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4172 |
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