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Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding
As part of the G-protein coupled receptor (GPCR) family, metabotropic glutamate (mGlu) receptors play an important role as drug targets of cognitive diseases. Selective allosteric modulators of mGlu subtype 5 (mGlu(5)) have the potential to alleviate symptoms of numerous central nervous system disor...
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| Publicat a: | ACS Chem Neurosci |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6986193/ https://ncbi.nlm.nih.gov/pubmed/31132237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00227 |
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