Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding

As part of the G-protein coupled receptor (GPCR) family, metabotropic glutamate (mGlu) receptors play an important role as drug targets of cognitive diseases. Selective allosteric modulators of mGlu subtype 5 (mGlu(5)) have the potential to alleviate symptoms of numerous central nervous system disor...

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Publicado en:ACS Chem Neurosci
Autores principales: Butkiewicz, Mariusz, Rodriguez, Alice L., Rainey, Shane E., Wieting, Joshua, Luscombe, Vincent B., Stauffer, Shaun R., Lindsley, Craig W., Conn, P. Jeffrey, Meiler, Jens
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986193/
https://ncbi.nlm.nih.gov/pubmed/31132237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00227
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