Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening

[Image: see text] Selective potentiators of glutamate response at metabotropic glutamate receptor subtype 5 (mGluR5) have exciting potential for the development of novel treatment strategies for schizophrenia. A total of 1,382 compounds with positive allosteric modulation (PAM) of the mGluR5 glutama...

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Auteurs principaux: Mueller, Ralf, Rodriguez, Alice L., Dawson, Eric S., Butkiewicz, Mariusz, Nguyen, Thuy T., Oleszkiewicz, Stephen, Bleckmann, Annalen, Weaver, C. David, Lindsley, Craig W., Conn, P. Jeffrey, Meiler, Jens
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2010
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857954/
https://ncbi.nlm.nih.gov/pubmed/20414370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn9000389
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