Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the Drug

Isoniazid (INH) is a cornerstone of antitubercular therapy. Mycobacterium tuberculosis complex bacteria are the only mycobacteria sensitive to clinically relevant concentrations of INH. All other mycobacteria, including M. marinum and M. avium subsp. paratuberculosis are resistant. INH requires acti...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Reingewertz, Tali H., Meyer, Tom, McIntosh, Fiona, Sullivan, Jaryd, Meir, Michal, Chang, Yung-Fu, Behr, Marcel A., Barkan, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985715/
https://ncbi.nlm.nih.gov/pubmed/31767723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01899-19
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