Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the Drug

Isoniazid (INH) is a cornerstone of antitubercular therapy. Mycobacterium tuberculosis complex bacteria are the only mycobacteria sensitive to clinically relevant concentrations of INH. All other mycobacteria, including M. marinum and M. avium subsp. paratuberculosis are resistant. INH requires acti...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Reingewertz, Tali H., Meyer, Tom, McIntosh, Fiona, Sullivan, Jaryd, Meir, Michal, Chang, Yung-Fu, Behr, Marcel A., Barkan, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985715/
https://ncbi.nlm.nih.gov/pubmed/31767723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01899-19
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