Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the Drug

Isoniazid (INH) is a cornerstone of antitubercular therapy. Mycobacterium tuberculosis complex bacteria are the only mycobacteria sensitive to clinically relevant concentrations of INH. All other mycobacteria, including M. marinum and M. avium subsp. paratuberculosis are resistant. INH requires acti...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Reingewertz, Tali H., Meyer, Tom, McIntosh, Fiona, Sullivan, Jaryd, Meir, Michal, Chang, Yung-Fu, Behr, Marcel A., Barkan, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985715/
https://ncbi.nlm.nih.gov/pubmed/31767723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01899-19
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