Identification of katG Mutations Associated with High-Level Isoniazid Resistance in Mycobacterium tuberculosis

Isoniazid (INH) is an effective first-line antituberculosis drug. KatG, a catalase-peroxidase, converts INH to an active form in Mycobacterium tuberculosis, and katG mutations are major causes of INH resistance. In the present study, we sequenced katG of 108 INH-resistant M. tuberculosis clinical is...

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Bibliografiske detaljer
Main Authors: Ando, Hiroki, Kondo, Yuji, Suetake, Toshinori, Toyota, Emiko, Kato, Seiya, Mori, Toru, Kirikae, Teruo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863633/
https://ncbi.nlm.nih.gov/pubmed/20211896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01691-09
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