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Identification of katG Mutations Associated with High-Level Isoniazid Resistance in Mycobacterium tuberculosis
Isoniazid (INH) is an effective first-line antituberculosis drug. KatG, a catalase-peroxidase, converts INH to an active form in Mycobacterium tuberculosis, and katG mutations are major causes of INH resistance. In the present study, we sequenced katG of 108 INH-resistant M. tuberculosis clinical is...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863633/ https://ncbi.nlm.nih.gov/pubmed/20211896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01691-09 |
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