Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the Drug

Isoniazid (INH) is a cornerstone of antitubercular therapy. Mycobacterium tuberculosis complex bacteria are the only mycobacteria sensitive to clinically relevant concentrations of INH. All other mycobacteria, including M. marinum and M. avium subsp. paratuberculosis are resistant. INH requires acti...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Reingewertz, Tali H., Meyer, Tom, McIntosh, Fiona, Sullivan, Jaryd, Meir, Michal, Chang, Yung-Fu, Behr, Marcel A., Barkan, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985715/
https://ncbi.nlm.nih.gov/pubmed/31767723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01899-19
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