Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition

Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that ar...

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Pubblicato in:Life Sci Alliance
Autori principali: Schukken, Klaske M, Lin, Yu-Chih, Bakker, Petra L, Schubert, Michael, Preuss, Stephanie F, Simon, Judith E, van den Bos, Hilda, Storchova, Zuzana, Colomé-Tatché, Maria, Bastians, Holger, Spierings, Diana CJ, Foijer, Floris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Life Science Alliance LLC 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985455/
https://ncbi.nlm.nih.gov/pubmed/31980556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900499
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