Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition

Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that ar...

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Dades bibliogràfiques
Publicat a:Life Sci Alliance
Autors principals: Schukken, Klaske M, Lin, Yu-Chih, Bakker, Petra L, Schubert, Michael, Preuss, Stephanie F, Simon, Judith E, van den Bos, Hilda, Storchova, Zuzana, Colomé-Tatché, Maria, Bastians, Holger, Spierings, Diana CJ, Foijer, Floris
Format: Artigo
Idioma:Inglês
Publicat: Life Science Alliance LLC 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985455/
https://ncbi.nlm.nih.gov/pubmed/31980556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900499
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