Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition

Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that ar...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Life Sci Alliance
Prif Awduron: Schukken, Klaske M, Lin, Yu-Chih, Bakker, Petra L, Schubert, Michael, Preuss, Stephanie F, Simon, Judith E, van den Bos, Hilda, Storchova, Zuzana, Colomé-Tatché, Maria, Bastians, Holger, Spierings, Diana CJ, Foijer, Floris
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Life Science Alliance LLC 2020
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985455/
https://ncbi.nlm.nih.gov/pubmed/31980556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900499
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