Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition

Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that ar...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Life Sci Alliance
Egile Nagusiak: Schukken, Klaske M, Lin, Yu-Chih, Bakker, Petra L, Schubert, Michael, Preuss, Stephanie F, Simon, Judith E, van den Bos, Hilda, Storchova, Zuzana, Colomé-Tatché, Maria, Bastians, Holger, Spierings, Diana CJ, Foijer, Floris
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Life Science Alliance LLC 2020
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985455/
https://ncbi.nlm.nih.gov/pubmed/31980556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900499
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