Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models

Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide and is characterized in part by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). The main pathological hallmark of PD is the intraneuronal accumulation of misfolded α-synuclei...

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Foilsithe in:Neurotherapeutics
Main Authors: Zhou, Hefeng, Shao, Min, Guo, Baojian, Li, Chuwen, Lu, Yucong, Yang, Xuanjun, ShengnanLi, Li, Haitao, Zhu, Qi, Zhong, Hanbing, Wang, Yuqiang, Zhang, Zaijun, Lu, Jiahong, Lee, Simon Ming-Yuen
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer International Publishing 2019
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985330/
https://ncbi.nlm.nih.gov/pubmed/31313223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00759-8
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