Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models

Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide and is characterized in part by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). The main pathological hallmark of PD is the intraneuronal accumulation of misfolded α-synuclei...

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Vydáno v:Neurotherapeutics
Hlavní autoři: Zhou, Hefeng, Shao, Min, Guo, Baojian, Li, Chuwen, Lu, Yucong, Yang, Xuanjun, ShengnanLi, Li, Haitao, Zhu, Qi, Zhong, Hanbing, Wang, Yuqiang, Zhang, Zaijun, Lu, Jiahong, Lee, Simon Ming-Yuen
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985330/
https://ncbi.nlm.nih.gov/pubmed/31313223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00759-8
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