Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson’s disease models through activating the MEF2-PGC1α and BDNF/CREB pathways

T-006, a new derivative of tetramethylpyrazine, has been recently found to protect against 6-hydroxydopamine (6-OHDA)-induced neuronal damage and clear α-synuclein (α-syn) by enhancing proteasome activity in an α-syn transgenic Parkinson’s disease (PD) model. The effect of T-006 on the 1-methyl-4-ph...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Chen, Haiyun, Cao, Jie, Zha, Ling, Wang, Peile, Liu, Zheng, Guo, Baojian, Zhang, Gaoxiao, Sun, Yewei, Zhang, Zaijun, Wang, Yuqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425444/
https://ncbi.nlm.nih.gov/pubmed/32710729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103551
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