Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy

TBN, a novel tetramethylpyrazine derivative armed with a powerful free radical-scavenging nitrone moiety, has been reported to reduce cerebral infarction in rats through multi-functional mechanisms of action. Here we study the therapeutic effects of TBN on non-human primate model of stroke. Thirty m...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhang, Zaijun, Zhang, Gaoxiao, Sun, Yewei, Szeto, Samuel S. W., Law, Henry C. H., Quan, Quan, Li, Guohui, Yu, Pei, Sho, Eiketsu, Siu, Michael K. W., Lee, Simon M. Y., Chu, Ivan K., Wang, Yuqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107909/
https://ncbi.nlm.nih.gov/pubmed/27841332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37148
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