A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

Glutamate-induced excitotoxicity is one of the main causes of neuronal cell death in stroke. Compound 22a has been previously reported as a promising neuroprotective compound derived from tetramethylpyrazine, which is a widely used active ingredient of traditional Chinese medicine Chuanxiong (Ligust...

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Pubblicato in:Front Neurosci
Autori principali: Chen, Haiyun, Cao, Jie, Zhu, Zeyu, Zhang, Gaoxiao, Shan, Luchen, Yu, Pei, Wang, Yuqiang, Sun, Yewei, Zhang, Zaijun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104130/
https://ncbi.nlm.nih.gov/pubmed/30158850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00567
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