Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems

Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate. Here we investigated the sorting mechanisms of endogenous MAPT in mature primary neurons using microfluidic chambers (MFCs) where cell compartments...

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Vydáno v:Autophagy
Hlavní autoři: Balaji, Varun, Kaniyappan, Senthilvelrajan, Mandelkow, Eckhard, Wang, Yipeng, Mandelkow, Eva-Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984766/
https://ncbi.nlm.nih.gov/pubmed/30145931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1509607
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