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Impact of Classical Strain Improvement of Penicillium rubens on Amino Acid Metabolism during β-Lactam Production

To produce high levels of β-lactams, the filamentous fungus Penicillium rubens (previously named Penicillium chrysogenum) has been subjected to an extensive classical strain improvement (CSI) program during the last few decades. This has led to the accumulation of many mutations that were spread ove...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Wu, Min, Crismaru, Ciprian G., Salo, Oleksandr, Bovenberg, Roel A. L., Driessen, Arnold J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974646/
https://ncbi.nlm.nih.gov/pubmed/31757830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01561-19
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