Deregulation of secondary metabolism in a histone deacetylase mutant of Penicillium chrysogenum

The Pc21 g14570 gene of Penicillium chrysogenum encodes an ortholog of a class 2 histone deacetylase termed HdaA which may play a role in epigenetic regulation of secondary metabolism. Deletion of the hdaA gene induces a significant pleiotropic effect on the expression of a set of polyketide synthas...

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Publicado en:Microbiologyopen
Autores principales: Guzman‐Chavez, Fernando, Salo, Oleksandr, Samol, Marta, Ries, Marco, Kuipers, Jeroen, Bovenberg, Roel A. L., Vreeken, Rob J., Driessen, Arnold J. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182556/
https://ncbi.nlm.nih.gov/pubmed/29575742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mbo3.598
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