Genomic mutational analysis of the impact of the classical strain improvement program on β–lactam producing Penicillium chrysogenum

BACKGROUND: Penicillium chrysogenum is a filamentous fungus that is employed as an industrial producer of β–lactams. The high β–lactam titers of current strains is the result of a classical strain improvement program (CSI) starting with a wild-type like strain more than six decades ago. This involve...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Genomics
Auteurs principaux: Salo, Oleksandr V., Ries, Marco, Medema, Marnix H., Lankhorst, Peter P., Vreeken, Rob J., Bovenberg, Roel A. L., Driessen, Arnold J. M.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647614/
https://ncbi.nlm.nih.gov/pubmed/26572918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-2154-4
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