Increased Penicillin Production in Penicillium chrysogenum Production Strains via Balanced Overexpression of Isopenicillin N Acyltransferase

Intense classical strain improvement has yielded industrial Penicillium chrysogenum strains that produce high titers of penicillin. These strains contain multiple copies of the penicillin biosynthesis cluster encoding the three key enzymes: δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine synthetase (ACVS),...

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Detaylı Bibliyografya
Asıl Yazarlar: Weber, Stefan S., Polli, Fabiola, Boer, Rémon, Bovenberg, Roel A. L., Driessen, Arnold J. M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2012
Konular:
Biotechnology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457468/
https://ncbi.nlm.nih.gov/pubmed/22865068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01529-12
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