Increased Penicillin Production in Penicillium chrysogenum Production Strains via Balanced Overexpression of Isopenicillin N Acyltransferase

Intense classical strain improvement has yielded industrial Penicillium chrysogenum strains that produce high titers of penicillin. These strains contain multiple copies of the penicillin biosynthesis cluster encoding the three key enzymes: δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine synthetase (ACVS),...

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Bibliografiska uppgifter
Huvudupphovsmän: Weber, Stefan S., Polli, Fabiola, Boer, Rémon, Bovenberg, Roel A. L., Driessen, Arnold J. M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
Ämnen:
Biotechnology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457468/
https://ncbi.nlm.nih.gov/pubmed/22865068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01529-12
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