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Increased Penicillin Production in Penicillium chrysogenum Production Strains via Balanced Overexpression of Isopenicillin N Acyltransferase

Intense classical strain improvement has yielded industrial Penicillium chrysogenum strains that produce high titers of penicillin. These strains contain multiple copies of the penicillin biosynthesis cluster encoding the three key enzymes: δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine synthetase (ACVS),...

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Hlavní autoři: Weber, Stefan S., Polli, Fabiola, Boer, Rémon, Bovenberg, Roel A. L., Driessen, Arnold J. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457468/
https://ncbi.nlm.nih.gov/pubmed/22865068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01529-12
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