Production of functionally active Penicillium chrysogenum isopenicillin N synthase in the yeast Hansenula polymorpha

BACKGROUND: β-Lactams like penicillin and cephalosporin are among the oldest known antibiotics used against bacterial infections. Industrially, penicillin is produced by the filamentous fungus Penicillium chrysogenum. Our goal is to introduce the entire penicillin biosynthesis pathway into the methy...

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Main Authors: Gidijala, Loknath, Bovenberg, Roel AL, Klaassen, Paul, van der Klei, Ida J, Veenhuis, Marten, Kiel, Jan AKW
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2287180/
https://ncbi.nlm.nih.gov/pubmed/18366686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-8-29
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