Biological characterization of new inhibitors of microsomal PGE synthase‐1 in preclinical models of inflammation and vascular tone

BACKGROUND AND PURPOSE: Microsomal PGE synthase‐1 (mPGES‐1), the inducible synthase that catalyses the terminal step in PGE(2) biosynthesis, is of high interest as therapeutic target to treat inflammation. Inhibition of mPGES‐1 is suggested to be safer than traditional NSAIDs, and recent data demons...

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書目詳細資料
發表在:Br J Pharmacol
Main Authors: Larsson, Karin, Steinmetz, Julia, Bergqvist, Filip, Arefin, Samsul, Spahiu, Linda, Wannberg, Johan, Pawelzik, Sven‐Christian, Morgenstern, Ralf, Stenberg, Patric, Kublickiene, Karolina, Korotkova, Marina, Jakobsson, Per‐Johan
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965680/
https://ncbi.nlm.nih.gov/pubmed/31404942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14827
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