Biological characterization of new inhibitors of microsomal PGE synthase‐1 in preclinical models of inflammation and vascular tone

BACKGROUND AND PURPOSE: Microsomal PGE synthase‐1 (mPGES‐1), the inducible synthase that catalyses the terminal step in PGE(2) biosynthesis, is of high interest as therapeutic target to treat inflammation. Inhibition of mPGES‐1 is suggested to be safer than traditional NSAIDs, and recent data demons...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Larsson, Karin, Steinmetz, Julia, Bergqvist, Filip, Arefin, Samsul, Spahiu, Linda, Wannberg, Johan, Pawelzik, Sven‐Christian, Morgenstern, Ralf, Stenberg, Patric, Kublickiene, Karolina, Korotkova, Marina, Jakobsson, Per‐Johan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
Onderwerpen:
Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965680/
https://ncbi.nlm.nih.gov/pubmed/31404942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14827
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