Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1

Microsomal prostaglandin E synthase-1 (MPGES1) is induced during an inflammatory reaction from low basal levels by pro-inflammatory cytokines and subsequently involved in the production of the important mediator of inflammation, prostaglandin E(2). Nonsteroidal anti-inflammatory drugs prevent prosta...

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Detalhes bibliográficos
Main Authors: Pawelzik, Sven-Christian, Uda, Narasimha Rao, Spahiu, Linda, Jegerschöld, Caroline, Stenberg, Patric, Hebert, Hans, Morgenstern, Ralf, Jakobsson, Per-Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937957/
https://ncbi.nlm.nih.gov/pubmed/20605783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114454
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