Biological characterization of new inhibitors of microsomal PGE synthase‐1 in preclinical models of inflammation and vascular tone

BACKGROUND AND PURPOSE: Microsomal PGE synthase‐1 (mPGES‐1), the inducible synthase that catalyses the terminal step in PGE(2) biosynthesis, is of high interest as therapeutic target to treat inflammation. Inhibition of mPGES‐1 is suggested to be safer than traditional NSAIDs, and recent data demons...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Larsson, Karin, Steinmetz, Julia, Bergqvist, Filip, Arefin, Samsul, Spahiu, Linda, Wannberg, Johan, Pawelzik, Sven‐Christian, Morgenstern, Ralf, Stenberg, Patric, Kublickiene, Karolina, Korotkova, Marina, Jakobsson, Per‐Johan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965680/
https://ncbi.nlm.nih.gov/pubmed/31404942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14827
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados