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Inhibition of microsomal PGE synthase‐1 reduces human vascular tone by increasing PGI(2): a safer alternative to COX‐2 inhibition
BACKGROUND AND PURPOSE: The side effects of cyclooxygenase‐2 (COX‐2) inhibitors on the cardiovascular system could be associated with reduced prostaglandin (PG)I(2) synthesis. Microsomal PGE synthase‐1 (mPGES‐1) catalyses the formation of PGE(2) from COX‐derived PGH(2). This enzyme is induced under...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5660006/ https://ncbi.nlm.nih.gov/pubmed/28675448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13939 |
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