A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary

cis-Regulatory communication is crucial in mammalian development and is thought to be restricted by the spatial partitioning of the genome in topologically associating domains (TADs). Here, we discovered that the Xist locus is regulated by sequences in the neighboring TAD. In particular, the promote...

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Pubblicato in:Mol Cell
Autori principali: Galupa, Rafael, Nora, Elphège Pierre, Worsley-Hunt, Rebecca, Picard, Christel, Gard, Chris, van Bemmel, Joke Gerarda, Servant, Nicolas, Zhan, Yinxiu, El Marjou, Fatima, Johanneau, Colin, Diabangouaya, Patricia, Le Saux, Agnès, Lameiras, Sonia, Pipoli da Fonseca, Juliana, Loos, Friedemann, Gribnau, Joost, Baulande, Sylvain, Ohler, Uwe, Giorgetti, Luca, Heard, Edith
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964159/
https://ncbi.nlm.nih.gov/pubmed/31759823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.030
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