A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary

cis-Regulatory communication is crucial in mammalian development and is thought to be restricted by the spatial partitioning of the genome in topologically associating domains (TADs). Here, we discovered that the Xist locus is regulated by sequences in the neighboring TAD. In particular, the promote...

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Publicado no:Mol Cell
Main Authors: Galupa, Rafael, Nora, Elphège Pierre, Worsley-Hunt, Rebecca, Picard, Christel, Gard, Chris, van Bemmel, Joke Gerarda, Servant, Nicolas, Zhan, Yinxiu, El Marjou, Fatima, Johanneau, Colin, Diabangouaya, Patricia, Le Saux, Agnès, Lameiras, Sonia, Pipoli da Fonseca, Juliana, Loos, Friedemann, Gribnau, Joost, Baulande, Sylvain, Ohler, Uwe, Giorgetti, Luca, Heard, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964159/
https://ncbi.nlm.nih.gov/pubmed/31759823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.030
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