A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary

cis-Regulatory communication is crucial in mammalian development and is thought to be restricted by the spatial partitioning of the genome in topologically associating domains (TADs). Here, we discovered that the Xist locus is regulated by sequences in the neighboring TAD. In particular, the promote...

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Bibliografski detalji
Izdano u:Mol Cell
Glavni autori: Galupa, Rafael, Nora, Elphège Pierre, Worsley-Hunt, Rebecca, Picard, Christel, Gard, Chris, van Bemmel, Joke Gerarda, Servant, Nicolas, Zhan, Yinxiu, El Marjou, Fatima, Johanneau, Colin, Diabangouaya, Patricia, Le Saux, Agnès, Lameiras, Sonia, Pipoli da Fonseca, Juliana, Loos, Friedemann, Gribnau, Joost, Baulande, Sylvain, Ohler, Uwe, Giorgetti, Luca, Heard, Edith
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964159/
https://ncbi.nlm.nih.gov/pubmed/31759823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.030
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